I got a couple of neat machines going in this Balatro run. With the Oops! All Sixes joker (which doubles the chances of any random roll) and Hanging Chad (which makes the first card you play play three times), I was able to make Lucky cards trigger which — in addition to the mult and $ — pumped up the Lucky Cat all the was the 12.75X.
The Astronomer got me free planets, which pumped up the Constellation, which got to around 6X. I was regularly getting around 5000 mult.
That’s still not enough to get you into scientific notation range, nor to get through Ante 12. I probably should have tried harder to replace the astronomer once I had tons of money and to have found another source of chip bonuses. Well, I guess that’s why I’ll end up playing this for several more months.